Effects of Leucine on in Vitro Protein Synthesis and Degradation in Rat Skeletal Muscles

作者: Soon-Ok Chang Hong , Donald K. Layman

DOI: 10.1093/JN/114.7.1204

关键词: LeucineInternal medicineEndocrinologyProtein degradationStreptozotocinProtein turnoverProtein biosynthesisBiochemistryBiologyStimulationMetabolismAmino acid

摘要: … To our knowledge, in vitro effects of leucine on skeletal muscle … in isolated muscles, and the in vivo effects of leucine are … Clinical studies have shown that infusion of leucine into …

参考文章(15)
M A McNurlan, E B Fern, P J Garlick, Failure of leucine to stimulate protein synthesis in vivo Biochemical Journal. ,vol. 204, pp. 831- 838 ,(1982) , 10.1042/BJ2040831
R M Fulks, J B Li, A L Goldberg, Effects of insulin, glucose, and amino acids on protein turnover in rat diaphragm. Journal of Biological Chemistry. ,vol. 250, pp. 290- 298 ,(1975) , 10.1016/S0021-9258(19)42013-9
Jeanne B. Li, Richard M. Fulks, Alfred L. Goldberg, Evidence That the Intracellular Pool of Tyrosine Serves as Precursor for Protein Synthesis in Muscle Journal of Biological Chemistry. ,vol. 248, pp. 7272- 7275 ,(1973) , 10.1016/S0021-9258(19)43388-7
B. Chua, D.L. Siehl, H.E. Morgan, Effect of leucine and metabolites of branched chain amino acids on protein turnover in heart. Journal of Biological Chemistry. ,vol. 254, pp. 8358- 8362 ,(1979) , 10.1016/S0021-9258(19)86898-9
M.E. Tischler, M. Desautels, A.L. Goldberg, Does leucine, leucyl-tRNA, or some metabolite of leucine regulate protein synthesis and degradation in skeletal and cardiac muscle? Journal of Biological Chemistry. ,vol. 257, pp. 1613- 1621 ,(1982) , 10.1016/S0021-9258(19)68081-6
H.E. Morgan, L.S. Jefferson, E.B. Wolpert, D.E. Rannels, Regulation of protein synthesis in heart muscle. II. Effect of amino acid levels and insulin on ribosomal aggregation. Journal of Biological Chemistry. ,vol. 246, pp. 2163- 2170 ,(1971) , 10.1016/S0021-9258(19)77203-2
Q. R. Rogers, A. E. Harper, Amino Acid Diets and Maximal Growth in the Rat Journal of Nutrition. ,vol. 87, pp. 267- 273 ,(1965) , 10.1093/JN/87.3.267
Jeanne B. Li, Leonard S. Jefferson, Influence of amino acid availability on protein turnover in perfused skeletal muscle. Biochimica et Biophysica Acta. ,vol. 544, pp. 351- 359 ,(1978) , 10.1016/0304-4165(78)90103-4