Leucine improves protein nutritional status and regulates hepatic lipid metabolism in calorie-restricted rats

摘要: Several studies have highlighted the potential of leucine supplementation for treatment metabolic diseases including type 2 diabetes and obesity. Caloric restriction is a common approach to improve health in diabetic obese subjects. However, very few assessed effects calorie-restricted animals. Rats were subjected 30% diet 6 weeks study on protein status markers lipid metabolism. reduced body weight. increased intake preserved lean mass improved anabolism as indicated by circulating levels albumin insulin-like growth factor-1 (IGF-1), liver expression IGF-1 messenger RNA. Leucine also interleukin-6 leptin but did not affect tumour necrosis factor-α monocyte chemotactic protein-1 concentrations. Ketone bodies rats consuming leucine-rich diet, we observed no changes cholesterol or triglycerides peroxisome proliferator activated receptor-α glucose-6-phosphatase, whereas 3-hydroxy-3-methyl-glutaryl-CoA reductase (HMG-CoA) sterol regulatory element-binding transcription factor 1. A during caloric whole anabolism. In addition, modulated hepatic These results indicate that may be useful preventing excessive waste conditions large weight loss. Copyright © 2013 John Wiley & Sons, Ltd.