Patterns of inflammation and the use of reversibility testing in smokers with airway complaints.

摘要: Although both smoking and respiratory complaints are very common, tools to improve diagnostic accuracy scarce in primary care. This study aimed reveal what inflammatory patterns prevail clinically established diagnosis groups, factors associated with eosinophilia. Induced sputum blood plasma of 59 care patients COPD (n = 17), asthma 11), chronic bronchitis (CB, n 14) smokers no ('healthy smokers', 17) were collected, as well lung function, history clinical work-up. Patterns markers per eosinophilia analyzed by multiple regression analyses, the differences expressed odds ratios (OR) 95% confidence intervals. Multivariately, was significantly raised plasma-LBP (OR 1.2 [1.04–1.37]) sTNF-R55 1.01 [1.001–1.01]), while HS lowered 0.8 [0.72–0.95]). Asthma characterized higher eosinophilic counts 1.3 [1.05–1.54]), CB showed a proportion lymphocytic 1.5 [1.12–1.9]). Sputum reversibility after adjusting for smoking, age, gender allergy. panel cells mediators discernable groups disease. so-called healthy consistent opposite associations LBP, bronchitics relatively predominant inflammation compared other groups. Only remained across spectrum disease airway complaints.