Schemes of flux control in a model of Saccharomyces cerevisiae glycolysis
作者： Leighton Pritchard , Douglas B. Kell
DOI: 10.1046/J.1432-1033.2002.03055.X
关键词: Phosphofructokinase 、 Biochemistry 、 Limiting 、 Hexose transport 、 Glycolysis 、 Biological system 、 Saccharomyces cerevisiae 、 Flux control 、 High flux 、 Flux (metabolism) 、 Biology
摘要: We used parameter scanning to emulate changes the limiting rate for steps in a fitted model of glucose-derepressed yeast glycolysis. Three flux-control regimes were observed, two which under dominant control hexose transport, accordance with various experimental studies and other predictions. A third regime phosphofructokinase exerted glycolytic flux was also found, but it appeared be physiologically unreachable by this model, all realistically obtainable featured transport as step involving high control.
manchester.ac.uk
strath.ac.uk参考文章(50)
E. Reifenberger, K. Freidel, M. Ciriacy, Identification of novel HXT genes in Saccharomyces cerevisiae reveals the impact of individual hexose transporters on qlycolytic flux Molecular Microbiology. ,vol. 16, pp. 157- 167 ,(1995) , 10.1111/J.1365-2958.1995.TB02400.X
Ian T. Jolliffe, Principal Component Analysis ,(1986)
Thomas DANDEKAR, Stefan SCHUSTER, Berend SNEL, Martijn HUYNEN, Peer BORK, Pathway alignment: application to the comparative analysis of glycolytic enzymes. Biochemical Journal. ,vol. 343, pp. 115- 124 ,(1999) , 10.1042/BJ3430115
Manfred Rizzi, Michael Baltes, Uwe Theobald, Matthias Reuss, In vivo analysis of metabolic dynamics inSaccharomyces cerevisiae: II. Mathematical model Biotechnology and Bioengineering. ,vol. 55, pp. 592- 608 ,(1997) , 10.1002/(SICI)1097-0290(19970820)55:4<592::AID-BIT2>3.0.CO;2-C
H. Kacser, J. A. Burns, H. Kacser, D. A. Fell, The control of flux Biochemical Society Transactions. ,vol. 23, pp. 341- 366 ,(1995) , 10.1042/BST0230341
Ronald J. Wonnacott, Thomas H. Wonnacott, Rj Op Wonnacott, Neil A. Weiss, Mcneil, Suresh C. Gupto, Prem S. Mann, Fask, A. M. Plews, Introductory statistics ,(1969)
A. D. Shaw, M. K. Winson, A. M. Woodward, A. C. McGovern, H. M. Davey, N. Kaderbhai, D. Broadhurst, R. J. Gilbert, J. Taylor, É. M. Timmins, R. Goodacre, D. B. Kell, B. K. Alsberg, J. J. Rowland, Rapid analysis of high-dimensional bioprocesses using multivariate spectroscopies and advanced chemometrics. Advances in Biochemical Engineering \/ Biotechnology. ,vol. 66, pp. 83- 113 ,(1999) , 10.1007/3-540-48773-5_3
Reinhart Heinrich, Stefan Schuster, The Regulation of Cellular Systems ,(1996)
Y Kashiwaya, K Sato, N Tsuchiya, S Thomas, D A Fell, R L Veech, J V Passonneau, Control of glucose utilization in working perfused rat heart. Journal of Biological Chemistry. ,vol. 269, pp. 25502- 25514 ,(1994) , 10.1016/S0021-9258(18)47278-X
Anthony H. Rose, Energy-Yielding Metabolism Chemical Microbiology (Third Edition)#R##N#An Introduction to Microbial Physiology. pp. 120- 161 ,(1968) , 10.1007/978-1-4899-6567-7_6