The development of an environmentally benign synthesis of sildenafil citrate (Viagra™) and its assessment by Green Chemistry metrics
作者： Peter J. Dunn , Stephen Galvin , Kevin Hettenbach
DOI: 10.1039/B312329D
关键词: Sildenafil 、 Chemical technology 、 Computer science 、 Nanotechnology 、 Process development 、 Process engineering 、 Green chemistry metrics
摘要: … The process development and scale-up of the sildenafil citrate process is reviewed. Key environmental metrics are reported at several time points during the development process. …
rsc.org
sci-hub.se 参考文章(5)
David J. C. Constable, Alan D. Curzons, Virginia L. Cunningham, Metrics to ‘green’ chemistry—which are the best? Green Chemistry. ,vol. 4, pp. 521- 527 ,(2002) , 10.1039/B206169B
Alan D. Curzons, David N. Mortimer, David J. C. Constable, Virginia L. Cunningham, So you think your process is green, how do you know?—Using principles of sustainability to determine what is green–a corporate perspective Green Chemistry. ,vol. 3, pp. 1- 6 ,(2001) , 10.1039/B007871I
Harriet W. Hamilton, Daniel F. Ortwine, Donald F. Worth, James A. Bristol, Synthesis and structure-activity relationships of pyrazolo[4,3-d]pyrimidin-7-ones as adenosine receptor antagonists Journal of Medicinal Chemistry. ,vol. 30, pp. 91- 96 ,(1987) , 10.1021/JM00384A016
David J. Dale, Peter J. Dunn, Clare Golightly, Michael L. Hughes, Philip C. Levett, Andrew K. Pearce, Patricia M. Searle, Gordon Ward, Albert S. Wood, The Chemical Development of the Commercial Route to Sildenafil: A Case History Organic Process Research & Development. ,vol. 4, pp. 17- 22 ,(2000) , 10.1021/OP9900683
B. Trost, The atom economy--a search for synthetic efficiency Science. ,vol. 254, pp. 1471- 1477 ,(1991) , 10.1126/SCIENCE.1962206