Isolation and characterization of a tadalafil analogue, N-cyclopentyl nortadalafil in health supplement.
作者： Yimin Xu , Chee-Leong Kee , Xiaowei Ge , Min-Yong Low , Hwee-Ling Koh
DOI: 10.1016/J.JPBA.2015.08.005
关键词: Mass spectrometry 、 Chromatography 、 Tandem mass spectrometry 、 Piperazinedione 、 Electrospray ionization 、 Moiety 、 Chemical structure 、 High-performance liquid chromatography 、 Chemistry 、 Nuclear magnetic resonance spectroscopy
摘要: A tadalafil analogue was detected for the first time during screening of a health supplement undeclared sexual enhancement drugs. The compound had been isolated and purified by preparative high-pressure liquid chromatography (HPLC). Its chemical structure elucidated using high-resolution mass spectrometry (HRMS), electrospray ionization tandem (ESI-MS/MS) nuclear magnetic resonance (NMR) spectroscopy. protonated molecular ion at m/z 444 with formula C26H25N3O4. data obtained from MS analysis suggested that N-methyl group on piperazinedione moiety substituted -C5H9 group. Analysis NMR performed characterized as cyclopentyl moiety. named N-cyclopentyl nortadalafil.
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