作者: Suresh Mandava , Bogonda Ganganna , Jungjoong Hwang , Younchang Jang , Jiho Hwang
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摘要: A number of phosphodiesterase 5 (PDE5) inhibitors approved by authorities have been used successfully in the treatment erectile dysfunction. These medicines must be prescribed carefully due to their adverse effects, but they and analogues are being illegally added dietary supplements. illegal supplements pose a significant risk public health. Several dimeric tadalafil synthesized for use as reference standards inspection functional foods that mainly advertised sexual enhancement products. During course this synthesis, 1-[bis(dimethylamino)methylene]-1H-1,2,3-triazolo[4,5-b]pyridinium 3-oxid hexafluorophosphate (HATU) was proven reagent choice amide coupling produce these analogues. Moreover, trans-isomer structures tentatively assigned isolated (bisprehomotadalafil bisprecyclopentyltadalafil) found now revised cis-isomer structures.