Identification and structural elucidation of three new tadalafil analogues found in a dietary supplement.

作者: Ji Hyun Lee , Suresh Mandava , Sun Young Baek , Yong-Moon Lee

DOI: 10.1016/J.JPBA.2015.10.039

关键词:

摘要: Compounds elucidated as new tadalafil analogues were found to be adulterated in a dietary supplement and detected during routine analysis by HPLC with photodiode array detection. The UV spectra of these compounds almost identical that tadalafil. unknown isolated preparative quadrupole-time-of-flight MS NMR spectroscopy. Two identified cyclopentyltadalafil trans-cyclopentyltadalafil, from the substitution N-methyl group cyclopentyl group. Another analogue was dimeric form an N-cyclopentyl This represents first report elucidation used adulterants supplement.

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