Identification of a new tadalafil analogue in an adulterated dietary supplement: trans-Bisprehomotadalafil.
作者： Ji Hyun Lee , Hyung Joo Kim , Suresh Mandava , Jungjoong Hwang , Hyoung Joon Park
DOI: 10.1016/J.JPBA.2015.07.023
关键词: Stereochemistry 、 Bisprehomotadalafil 、 High-performance liquid chromatography 、 Dietary supplement 、 Tadalafil 、 Nuclear magnetic resonance spectroscopy 、 Piperidine 、 Tandem mass spectrometry 、 Proton NMR 、 Chemistry
摘要: A new tadalafil analogue was identified along with homotadalafil during routine screening of an adulterated dietary supplement using HPLC-DAD. The UV spectrum this almost identical that tadalafil. This compound isolated from the by semi-preparative HPLC and its structure subsequently elucidated performing Q-TOF/MS/MS NMR spectroscopic experiments. spectral data indicate is a dimeric consists ethylamino group two pretadalafil moieties. NOE experiments comparison (1)H spectra trans-tadalafil suggested trans-relationship between substituents on piperidine rings in
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