Counterfeit phosphodiesterase type 5 inhibitors pose significant safety risks

摘要: Counterfeit drugs are inherently dangerous and a growing problem; counterfeiters becoming increasingly sophisticated. Growth of the counterfeit medication market is attributable in part to phosphodiesterase type 5 inhibitor (PDE5i) medications for erectile dysfunction (ED). Millions PDE5is seized yearly account bulk all pharmaceutical product seizures. It has been estimated that up 2.5 million men Europe exposed illicit sildenafil, suggesting there may be as many illegal legal users sildenafil. Analysis contents shows inconsistent doses active ingredients (from 0% > 200% labelled dose), contaminants (including talcum powder, commercial paint printer ink) alternative potentially hazardous. In one analysis, only 10.1% samples were within 10% tablet strength. Estimates place proportion sold over Internet from 44% 90%. Of who purchase prescription-only ED without prescription, 67% do so using Internet. pose direct indirect risks health, including circumvention healthcare system. More than 30% reported no interaction when purchasing medications. Because 65% actually had ED, these missed an opportunity evaluation comorbidities (e.g. diabetes hypertension). Globally, increased obstacles necessary combat counterfeiting, fines penalties. The worldwide nature problem requires proper coordination between countries ensure adequate enforcement. Locally, physicians treat need inform patients dangers ordering via