Isolation and structural elucidation of a new tadalafil analogue in health supplements: bisprenortadalafil
作者： Lee JiHyun Lee JiHyun , Park HanNa Park HanNa , B Ganganna , Jeong JiHye Jeong JiHye , Park SungKwan Park SungKwan
DOI: 10.1080/19440049.2016.1179134
关键词: Stereochemistry 、 Moiety 、 Piperidine 、 Tadalafil 、 High-performance liquid chromatography 、 Dietary supplement 、 Nuclear magnetic resonance spectroscopy 、 Nuclear Overhauser effect 、 Chemistry
摘要: A new tadalafil analogue was found, along with nortadalafil, using HPLC-DAD during the inspection of a health product sold without official approval. The separated semi-preparative HPLC system and its structure determined by combination mass spectrometry NMR spectroscopy. compound identified as in which N-methyl group replaced precursor moiety. Nuclear Overhauser effect spectroscopy experiments suggested cis-relationship between substituents on piperidine ring
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