The Lupus Ratio Test - An Interlaboratory Study on the Detection of Lupus Anticoagulants by an APTT-based, Integrated, and Semi-quantitative Test From the Fifth International Survey of Lupus Anticoagulants - ISLA 5
作者： L. Barna-Cler , J. M. Taylor , D. A. Triplett , F. Wisløff , E. M. Jacobsen
关键词: Semi quantitative 、 Partial thromboplastin time 、 International survey 、 Ratio test 、 Systemic lupus erythematosus 、 Anticoagulant 、 Pathology 、 Reproducibility 、 Coagulopathy 、 Medicine 、 Chromatography
摘要: The Lupus Ratio (LR) test for lupus anticoagulants integrates screening, mixing with normal plasma and confirmation procedures into one assay. sensitivity reproducibility of the APTT based version this assay was tested in an interlaboratory study that part Fifth International Survey Anticoagulants (ISLA-5). One LA negative containing heparin, six positive plasmas a pooled (NP) were distributed to 31 laboratories world-wide together two reagents, high low phospholipid concentration. performed APTTs, each reagent, on 1:1 mixtures NP. ratio between clotting times divided by corresponding This final is LR plasma. overall found be 95.1%, normal, heparin-containing sample reported all laboratories. When results grouped low, medium plasmas, "consensus" regarding strength easily found. 85.0% agreement consensus. shows test, it possible obtain presence or absence as well semi-quantification inhibitor.
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