The Presence of CA19-9 in Serum and Saliva from Lewis Blood-group Negative Cancer Patients
作者： Shin Yazawa , Takayuki Asao , Hideaki Izawa , Yukio Miyamoto , Khushi L. Matta
DOI: 10.1111/J.1349-7006.1988.TB01624.X
关键词: Cancer 、 Fucosyltransferases 、 Endocrinology 、 Internal medicine 、 CA19-9 、 Leb antigen 、 Saliva 、 Antigen 、 Biology 、 Group ii 、 Guanosine Diphosphate Fucose 、 Immunology
摘要: Eighteen cancer patients showed high levels of CA19-9 in sera, even though the blood-group phenotypes their red blood cells were Le(a — b —). Seven these (group I) determined as —) from both and saliva consistently, whereas eleven other II) secreted either Lea or Leb antigen expression incompatible Lewis antigens. GDP-fucose: N-acetyl-glucosaminide a(1 × 4)-L-fucosyltransferase was demonstrated to be present salivas group I II. These results suggest that a cancer-associated alteration occurs patients.
sci-hub.se 参考文章(24)
Victor Ginsburg, Zenon Steplewski, Hilary Koprowski, John L. Magnani, Identification of the gastrointestinal and pancreatic cancer-associated antigen detected by monoclonal antibody 19-9 in the sera of patients as a mucin Cancer Research. ,vol. 43, pp. 5489- 5492 ,(1983)
Mei Yuan, Young S. Kim, Steven H. Itzkowitz, Alka Palekar, Linda D. Ferrell, Cancer-associated Alterations of Blood Group Antigen Expression in Human Colorectal Polyps Cancer Research. ,vol. 46, pp. 5976- 5984 ,(1986)
Kuhns W, Primus Fj, Schoentag R, ABH and Lewis blood group expression in colorectal carcinoma Cancer Research. ,vol. 47, pp. 1695- 1700 ,(1987)
J L Magnani, B Nilsson, M Brockhaus, D Zopf, Z Steplewski, H Koprowski, V Ginsburg, A monoclonal antibody-defined antigen associated with gastrointestinal cancer is a ganglioside containing sialylated lacto-N-fucopentaose II. Journal of Biological Chemistry. ,vol. 257, pp. 14365- 14369 ,(1982) , 10.1016/S0021-9258(19)45389-1
B C Del Villano, S Brennan, P Brock, C Bucher, V Liu, M McClure, B Rake, S Space, B Westrick, H Schoemaker, V R Zurawski, Radioimmunometric assay for a monoclonal antibody-defined tumor marker, CA 19-9. Clinical Chemistry. ,vol. 29, pp. 549- 552 ,(1983) , 10.1093/CLINCHEM/29.3.549
Shin Yazawa, Ragupathy Madiyalakan, M.Steven Piver, Khushi L. Matta, Elevated activities of blood group Le gene dependent α(1 → 3)-l-fucosyltransferase in human saliva of Lewis negative patients with epithelial ovarian cancer Cancer Letters. ,vol. 32, pp. 165- 169 ,(1986) , 10.1016/0304-3835(86)90115-1
Peter HANFLAND, Isolation and Purification of Lewis Blood‐Group Active Glycosphingolipids from the Plasma of Human O Leb Individuals FEBS Journal. ,vol. 87, pp. 161- 170 ,(1978) , 10.1111/J.1432-1033.1978.TB12363.X
Ragupathy Madiyalakan, Shin Yazawa, Joseph J. Barlow, Khushi L. Matta, Elevated serum α(1 → 3)-l-fucosyltransferase activity with synthetic low molecular weight acceptor in human ovarian cancer Cancer Letters. ,vol. 30, pp. 201- 205 ,(1986) , 10.1016/0304-3835(86)90089-3
Helmut Schenkel-Brunner, Hans Tuppy, Enzymes from Human Gastric Mucosa Conferring Blood‐Group A and B Specificities upon Erythrocytes FEBS Journal. ,vol. 17, pp. 218- 222 ,(1970) , 10.1111/J.1432-1033.1970.TB01156.X
D. M. Marcus, L. E. Cass, Glycosphingolipids with Lewis blood group activity: uptake by human erythrocytes. Science. ,vol. 164, pp. 553- 555 ,(1969) , 10.1126/SCIENCE.164.3879.553