Quorum Sensing in Staphylococci
作者： Richard P. Novick , Edward Geisinger
DOI: 10.1146/ANNUREV.GENET.42.110807.091640
关键词: Quorum sensing 、 Genetics 、 Biology 、 Microbiology 、 Effector 、 Regulation of gene expression 、 Gene 、 RNA 、 Virulence 、 Bacterial genetics 、 RNAIII
摘要: The staphylococcal agr locus encodes a quorum sensing (QS) system that controls the expression of virulence and other accessory genes by classical two-component signaling module. Like QS modalities in Gram-positive bacteria, an autoactivating peptide (AIP) is inducing ligand for AgrC, signal receptor. Unlike such systems, variants have arisen show strong cross-inhibition heterologous combinations, with important evolutionary implications. Also unlike effector global gene regulation major regulatory RNA, RNAIII. In this review, we describe functions system's elements, how they interact to bring about response, discuss role pathobiology. We conclude suggestion autoactivation, enzyme induction, can occur under suboptimal conditions distinguish self from non-self exclusive coordinated...
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