Use of geldanamycin and related compounds for treatment of fibrogenic disorders

摘要: A method for prophylaxis or treatment of a mammal, particularly human, at risk fibrogenic disorder is disclosed. The compositions and methods the invention are directed both to treatments existing disorders prevention thereof. Such include, but not limited to, connective tissue diseases, such as scleroderma (or systemic sclerosis), polymyositis, lupus erythematosis rheumatoid arthristis, other fibrotic disorders, including liver cirrhosis, keloid formation, interstitial nephritis pulmonary fibrosis. therapeutic composition according includes, agent, an inhibitor collagen promoter in pharmaceutically acceptable inert carrier vehicle, preferably local, topical, application. Exemplary inhibitors include those that interfere with heat shock protein 90 (Hsp 90) chaperone function, e.g., specific geldanamycin known Hsp90 macbecin I II, herbimycin, radcicol novobiocin.