Materials and methods for exploiting synthetic lethality in mismatch repair-deficient cancers
作者： Alan Ashworth , Christopher James Lord , Sarah Martin
DOI:
关键词: Suppressor 、 Synthetic lethality 、 DNA mismatch repair 、 MSH6 、 Function (biology) 、 DNA polymerase 、 Biology 、 MSH2 、 Cancer research 、 Gene
摘要: Therapeutic approaches to the treatment of DNA mismatch repair (MMR) deficient cancers are disclosed based on use complimentary gene-function and drug screening synthetic lethality for designing therapies where loss tumour suppressor function has occurred. The work is experiments using human MSH2, an integral component MMR pathway, applicable other genes in particular MLHl, MSH6, PMSl PMS 2. In MSH2 synthetically lethal with inhibition polymerase POLbeta. Deficiency MLHl γ (POLG) inhibition.
lens.org 参考文章(8)
Christophe Cazaux, Jean-Sébastien Hoffmann, Pascal Fons, Jean-Paul Reynes, Khalil Bouayadi, Michele Tiraby, Overexpression of DNA Polymerase β Sensitizes Mammalian Cells to 2′,3′-Deoxycytidine and 3′-Azido-3′-deoxythymidine Cancer Research. ,vol. 57, pp. 110- 116 ,(1997)
Naoki Maeda, Yasuo Kokai, Seiji Ohtani, Hiroeki Sahara, Takahiko Hada, Chisato Ishimaru, Isoko Kuriyama, Yuko Yonezawa, Hiroshi Iijima, Hiromi Yoshida, Noriyuki Sato, Yoshiyuki Mizushina, Anti-tumor effects of the glycolipids fraction from spinach which inhibited DNA polymerase activity. Nutrition and Cancer. ,vol. 57, pp. 216- 223 ,(2007) , 10.1080/01635580701277908
John Mackintosh, Alan Coates, Cheryl Swanson, Derek Raghavan, M. H. N. Tattersall, Chemotherapy of advanced colorectal cancer. A randomized trial of sequential methotrexate and 5-fluorouracil. American Journal of Clinical Oncology. ,vol. 10, pp. 210- 212 ,(1987) , 10.1097/00000421-198706000-00006
LM WANG, S BANERJEE, MUTATIONS IN DNA-POLYMERASE-BETA OCCUR IN BREAST, PROSTATE AND COLORECTAL TUMORS International Journal of Oncology. ,vol. 6, pp. 459- 463 ,(1995) , 10.3892/IJO.6.2.459
Y. Mizushina, N. Kasai, H. Iijima, F. Sugawara, H. Yoshida, K. Sakaguchi, Sulfo-quinovosyl-acyl-glycerol (SQAG), a eukaryotic DNA polymerase inhibitor and anti-cancer agent. Current Medicinal Chemistry - Anti-cancer Agents. ,vol. 5, pp. 613- 625 ,(2005) , 10.2174/156801105774574685
Yoshiyuki Mizushina, Shinji Kamisuki, Nobuyuki Kasai, Noriko Shimazaki, Masaharu Takemura, Hitomi Asahara, Stuart Linn, Shonen Yoshida, Akio Matsukage, Osamu Koiwai, Fumio Sugawara, Hiromi Yoshida, Kengo Sakaguchi, A Plant Phytotoxin, Solanapyrone A, Is an Inhibitor of DNA Polymerase β and λ Journal of Biological Chemistry. ,vol. 277, pp. 630- 638 ,(2002) , 10.1074/JBC.M105144200
F. Boudsocq, P. Benaim, Y. Canitrot, M. Knibiehler, F. Ausseil, J. P. Capp, A. Bieth, C. Long, B. David, I. Shevelev, E. Frierich-Heinecken, U. Hübscher, F. Amalric, G. Massiot, J. S. Hoffmann, C. Cazaux, Modulation of Cellular Response to Cisplatin by a Novel Inhibitor of DNA Polymerase β Molecular Pharmacology. ,vol. 67, pp. 1485- 1492 ,(2005) , 10.1124/MOL.104.001776
David A. Ostrov, Aruna S. Jaiswal, Satya Narayan, Compositions and methods of treating neoplasia ,(2008)