Inactivation of dna repair as an anticancer therapy

作者: Alberto Bardelli , Chris Torrance , Giovanni Germano

DOI:

关键词:

摘要: This invention relates to the modulation of DNA repair and nucleic acid editing mechanisms for use in treatment cancer. inactivation also screening new anti-cancer agents.

参考文章(15)
Katherine Lea Pogue-Geile, Soonmyung Paik, Defective mismatch repair and benefit from bevacizumab for colon cancer ,(2014)
Lili Liu, Stanton L. Gerson, Methoxyamine combinations in the treatment of cancer ,(2002)
Itaru Sonoda, Hideaki Tanami, Hiroyuki Izumi, Hisashi Takada, Akiko Furihata, Johji Inazawa, Kuniyasu Saigusa, Jun Inoue, Sana Yokoi, Shin Hayashi, Issei Imoto, Ayako Suzuki, Method for detecting cancer and a method for suppressing cancer ,(2006)
Minttu Kansikas, Minna Nyström, Päivi Peltomäki, Method to determine dna mismatch repair function ,(2012)
Paolo Ceppi, Silvia Novello, Alberto Cambieri, Marina Longo, Valentina Monica, Marco Lo Iacono, Matteo Giaj-Levra, Silvia Saviozzi, Marco Volante, Mauro Papotti, Giorgio Scagliotti, Polymerase eta mRNA expression predicts survival of non-small cell lung cancer patients treated with platinum-based chemotherapy. Clinical Cancer Research. ,vol. 15, pp. 1039- 1045 ,(2009) , 10.1158/1078-0432.CCR-08-1227
A Fedier, UB Ruefenacht, VA Schwarz, U Haller, D Fink, None, Increased sensitivity of p53-deficient cells to anticancer agents due to loss of Pms2 British Journal of Cancer. ,vol. 87, pp. 1027- 1033 ,(2002) , 10.1038/SJ.BJC.6600599
Amit Kumar Srivastava, Chunhua Han, Ran Zhao, Tiantian Cui, Yuntao Dai, Charlene Mao, Weiqiang Zhao, Xiaoli Zhang, Jianhua Yu, Qi-En Wang, Enhanced expression of DNA polymerase eta contributes to cisplatin resistance of ovarian cancer stem cells. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 112, pp. 4411- 4416 ,(2015) , 10.1073/PNAS.1421365112
Azizah B. Mohd, Brett Palama, Scott E. Nelson, Guy Tomer, Megan Nguyen, Xin Huo, Andrew B. Buermeyer, Truncation of the C-terminus of human MLH1 blocks intracellular stabilization of PMS2 and disrupts DNA mismatch repair DNA Repair. ,vol. 5, pp. 347- 361 ,(2006) , 10.1016/J.DNAREP.2005.11.001