METHODS OF TREATING CANCER AND/OR ENHANCING SENSITIVITY TO CANCER TREATMENT BY INCREASING TUMOR MUTATION BURDEN OR TUMOR INDELS
作者： Vincent Mark David
DOI:
关键词: PMS2 、 MSH6 、 DNA mismatch repair 、 Cancer 、 Cancer research 、 Medicine 、 MLH1 、 MSH2 、 Proofreading 、 Mutation
摘要: Methods of treating cancer or enhancing sensitivity to therapies, including immunotherapies by increasing tumor mutation burden, are provided. The methods use therapeutics directed against DNA polymerase proofreading and/or mismatch repair enzymes such as MLH1, MSH2, MSH6 PMS2. can be used alone, in tandem combination with other particular immunotherapies. Also provided antisense targeting enzymes.
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