DNA Damage and Repair Biomarkers of Immunotherapy Response.
作者： Kent W. Mouw , Michael S. Goldberg , Panagiotis A. Konstantinopoulos , Alan D. D'Andrea
DOI: 10.1158/2159-8290.CD-17-0226
关键词:
摘要: DNA-damaging agents are widely used in clinical oncology and exploit deficiencies tumor DNA repair. Given the expanding role of immune checkpoint blockade as a therapeutic strategy, interaction damage with system has recently come into focus, it is now clear that repair landscape an important driving response to blockade. Here, we summarize mechanisms by which genomic instability have been found shape antitumor describe efforts use biomarkers guide immune-directed therapies.Significance: Only subset patients respond blockade, reliable predictive needed therapy decisions. deficiency common among tumors, emerging experimental evidence suggests features associated therapies. Cancer Discov; 7(7); 675-93. ©2017 AACR.
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