New Opportunity to Formulate Intranasal Vaccines and Drug Delivery Systems Based on Chitosan.
作者： Roxana Popescu , Mihaela Violeta Ghica , Cristina-Elena Dinu-Pîrvu , Valentina Anuța , Dumitru Lupuliasa
DOI: 10.3390/IJMS21145016
关键词: Mucoadhesion 、 Zeta potential 、 Combinatorial chemistry 、 Chemistry 、 Bioavailability 、 Nasal administration 、 Active ingredient 、 Chitosan 、 Self-healing hydrogels 、 Drug delivery
摘要: In an attempt to develop drug delivery systems that bypass the blood-brain barrier (BBB) and prevent liver intestinal degradation, it was concluded nasal medication meets these criteria can be used for drugs have drawbacks. The aim of this review is present influence properties chitosan its derivatives (mucoadhesion, permeability enhancement, surface tension, zeta potential) on development suitable bioavailability various active pharmaceutical ingredients. Interactions between proteins, lipids, antigens, other molecules lead complexes their own applications or changing characteristics substances involved in bond (conformational changes, increased stability solubility, etc.). Chitosan actions (antibacterial, antifungal, immunostimulant, antioxidant, etc.) as such combination with from same class achieve a synergistic effect. applicability set out second part paper, where formulations based are described (vaccines, hydrogels, nanoparticles, nanostructured lipid carriers (NLC), powders, emulsions,
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