Progress and perspectives of brain-targeting lipid-based nanosystems via the nasal route in Alzheimer’s disease

摘要: Since health care systems dedicate substantial resources to Alzheimer's disease (AD), it poses an increasing challenge scientists and providers worldwide, especially that many decades of research in the medical field revealed no optimal effective treatment for this disease. The intranasal administration route seems be a preferable anti-AD drug delivery over oral one as demonstrates ability overcome related obstacles reflected low bioavailability, limited brain exposure undesired pharmacokinetics or side effects. This can bypass systemic circulation through intraneuronal extraneuronal pathways, providing truly needleless direct therapeutics due its large surface area, porous endothelial membrane, avoidance first-pass metabolism, ready accessibility. Among different nano-carrier developed, lipid-based nanosystems have become increasingly popular proven managing common symptoms AD when administered via nose-to-brain route, which provides answer circumventing BBB. design such nanocarriers could challenging since factors contribute quality final product. Hence, according authors, is recommended follow by methodology from early stage development ensure high product while saving efforts costs. review article aims draw attention up-to-date findings potential role developing forms management means addition highlighting significant applying QbD development.