Introduction: diet, epigenetic events and cancer prevention.

摘要: Epigenetics is defined as heritable changes in gene expression not associated with alterations DNA sequence.1 methylation, histone modifications, chromatin remodeling factors, and noncoding regulatory RNAs are all known to be involved epigenetic regulation of structure activity. These processes considered critical components normal development cellular differentiation, organogenesis, aging. Additionally, there mounting evidence that abnormalities causative factors several diseases, including cancer. Evidence also continues surface for constituents food dietary supplements influence expression, well an individual's risk developing some cancers. Since may susceptible caused by environmental they offer potential mechanistic explanations how diet modify cancer tumor behavior. The Division Cancer Prevention (DCP), National Institute (NCI), the Office Dietary Supplements (ODS), Director, Institutes Health (NIH), hosted symposium titled Diet, Epigenetic Events, , on September 26–27, 2007. The objectives were 1) identify voids impeding progress basic, translational, clinical research related use bioactive (BFCs) prevention, 2) provide information about new tools facilitate research. 2007 represented a continuation previous trans-Department Human Services workshop Methylation Processes held August, 2001. That gave rise number publications2 NCI Funding Opportunity Announcement (as Request Applications) led funding 10 projects collaboration ODS. support diet, events, prevention through active opportunities currently available NIH Guide …