Formation of periodic apneustic breathing by activation of the GABA-ergic system of the brain
作者： I. A. Tarakanov , E. A. Golovatyuk , E. R. Turskaya , V. A. Safonov
DOI: 10.1007/BF00791146
关键词: Antigen 、 Chemistry 、 Epitope 、 Immunogenicity 、 Conjugate 、 Anesthesia 、 Biophysics 、 Glutaraldehyde 、 Hapten 、 General Biochemistry, Genetics and Molecular Biology 、 General Medicine
摘要: The model of T-dependent dopamine-protein conjugates prepared by the glutaraldehyde method was used to study influence hapten valence and molecular weight on immunogenicity these conjugates. increased in range DA4-BSA--DA5,8-BSA--DA14-BSA decreased with further increase density. It assumed that partial tolerogenic properties DA18-22-BSA were due nonspecific mechanisms associated changes physical characteristics antigen during procedure conjugation, rather than specific mechanisms. latter are more typical for low substituted
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