Decline of life’s energy theory of ageing 2. Restoration of anabolic and regulatory processes

作者: Geoffrey F Grant , Tyler Parr

DOI: 10.1517/13543776.10.12.1885

关键词: InsulinHormoneAgeingStimulationEndocrinologyInternal medicineCalorie restrictionMelatoninBiologyDehydroepiandrosteroneAnabolism

摘要: The precipitous decline of anabolic hormone levels that occurs as humans and animals age results in a cellular energy production throughout the whole body. It is this allows deterioration body leads us to pose obvious questions: should we attempt re-establish hormonal synchrony mid-life levels? And, if restore both regulation will be revitalised stable metabolic status? answers these questions have significant social, economic personal implications. mind fail progressively, after mid-life, absence any restoration. failure due producing capacity individual cells an effect declining stimulation by hormones. lower levels, particularly dehydroepiandrosterone (DHEA) growth (GH), precede dysfunctional changes occur bodily tissues. A wealth literature multiple...

参考文章(63)
M P Czech, J K Klarlund, K A Yagaloff, A P Bradford, R E Lewis, Insulin receptor signaling. Activation of multiple serine kinases. Journal of Biological Chemistry. ,vol. 263, pp. 11017- 11020 ,(1988) , 10.1016/S0021-9258(18)37908-0
Vaddanahally T. Maddaiah, Raj K. Sharma, V. Balachandar, Iraj Rezvani, Platon J. Collipp, Shang-Yao Chen, Effect of Growth Hormone on Mitochondrial Protein Synthesis Journal of Biological Chemistry. ,vol. 248, pp. 4263- 4268 ,(1973) , 10.1016/S0021-9258(19)43766-6
Peter S. Riegel, Athletic Records and Human Endurance American Scientist. ,vol. 69, pp. 285- 290 ,(1981)
S. S. C. YEN, A. J. MORALES, O. KHORRAM, Replacement of DHEA in aging men and women. Potential remedial effects. Annals of the New York Academy of Sciences. ,vol. 774, pp. 128- 142 ,(1995) , 10.1111/J.1749-6632.1995.TB17377.X
Tyler Parr, Insulin exposure and unifying aging. Gerontology. ,vol. 45, pp. 121- 135 ,(1999) , 10.1159/000022075
Thord Rosén, Gudmundur Johannsson, Jan-Ove Johansson, Bengt-Åke Bengtsson, Consequences of growth hormone deficiency in adults and the benefits and risks of recombinant human growth hormone treatment. A review paper. Hormone Research in Paediatrics. ,vol. 43, pp. 93- 99 ,(1995) , 10.1159/000184245
Jake Powrie, Andrew Weissberger, Peter Sönksen, Growth hormone replacement therapy for growth hormone-deficient adults. Drugs. ,vol. 49, pp. 656- 663 ,(1995) , 10.2165/00003495-199549050-00002
V.T. Maddaiah, P.J. Collipp, J.H. Lin, J.L. Duffy, Growth hormone and liver mitochondria effect on morphology and protein turnover Biochemical Medicine. ,vol. 16, pp. 47- 54 ,(1976) , 10.1016/0006-2944(76)90007-7
BARNETT ZUMOFF, GLADYS W. STRAIN, JACOB KREAM, JOHN O'CONNOR, ROBERT S. ROSENFELD, JOSEPH LEVIN, DAVID K. FUKUSHIMA, Age variation of the 24-hour mean plasma concentrations of androgens, estrogens, and gonadotropins in normal adult men. The Journal of Clinical Endocrinology and Metabolism. ,vol. 54, pp. 534- 538 ,(1982) , 10.1210/JCEM-54-3-534
L. E. Bottiger, Regular Decline in Physical Working Capacity with Age BMJ. ,vol. 3, pp. 270- 271 ,(1973) , 10.1136/BMJ.3.5874.270