Supramolecular anchoring of DNA polyplexes in cyclodextrin-based polypseudorotaxane hydrogels for sustained gene delivery.
作者： Zibiao Li , Hui Yin , Zhongxing Zhang , Kerh Li Liu , Jun Li
DOI: 10.1021/BM300936X
关键词: Cyclodextrin 、 Supramolecular chemistry 、 Copolymer 、 Self-healing hydrogels 、 Ethylene glycol 、 Polymer chemistry 、 Chemical engineering 、 Methacrylate 、 Chemistry 、 Gene delivery 、 Cationic polymerization
摘要: A cyclodextrin-based supramolecular hydrogel system with supramolecularly anchored active cationic copolymer/plasmid DNA (pDNA) polyplexes was studied as a sustained gene delivery carrier. few biodegradable triblock copolymers of methoxy-poly(ethylene glycol)-b-poly(e-caprolactone)-b-poly[2-(dimethylamino)ethyl methacrylate] (MPEG-PCL-PDMAEMA) well-defined block lengths were prepared to condense pDNA. The MPEG-PCL-PDMAEMA exhibit good ability pDNA into 275–405 nm hydrophilic MPEG in the outer corona. corona imparted greater stability and also served an anchoring segment when encapsulated α-CD-based polypseudorotaxane hydrogels. More interestingly, resultant hydrogels able sustain release up 6 days. released form polyplex nanoparticles it bound electrostatically copolymers. Th...
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