Comparative studies of infectivity, immunogenicity and cross-protective efficacy of live attenuated influenza vaccines containing nucleoprotein from cold-adapted or wild-type influenza virus in a mouse model.
作者： Irina Isakova-Sivak , Daniil Korenkov , Tatiana Smolonogina , Tatiana Tretiak , Svetlana Donina
DOI: 10.1016/J.VIROL.2016.10.027
关键词: Virus 、 Immunity 、 Live attenuated influenza vaccine 、 Immunogenicity 、 Nucleoprotein 、 Heterologous 、 Immune system 、 Infectivity 、 Virology 、 Biology
摘要: This study sought to improve an existing live attenuated influenza vaccine (LAIV) by including nucleoprotein (NP) from wild-type virus rather than master donor virus (MDV). H7N9 LAIV reassortants with 6: 2 (NP from MDV) and 5: 3 (NP from wild-type virus) genome compositions were compared with regard to their growth characteristics, induction of humoral and cellular immune responses in mice, and ability to protect mice against homologous and heterologous challenge viruses. Although, in general, the 6: 2 reassortant …
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