Candida albicans-induced inflammatory response in human keratinocytes.
作者： U. Wollina , W. Kunkel , L. Bulling , C. Funfstuck , B. Knoll
DOI: 10.1111/J.1439-0507.2004.00976.X
关键词: Candida albicans 、 HaCaT 、 Keratinocyte 、 Cell growth 、 Cytokine 、 Virulence 、 Reactive oxygen species 、 Chemistry 、 Corpus albicans 、 Microbiology
摘要: Summary Candida albicans strains 3153a, ATCC 48867, CBS 2730, DSM 70014, and Vir 13 were cultivated sterile C. filtrates produced. The interaction of soluble Candida factors these infiltrates with human HaCaT keratinocytes was assayed in vitro. following parameters analyzed: cell proliferation, protein synthesis, nuclear matrix (NMP) 41 release, cytokine release (IL-1β, IL-2 receptor, IL-6, IL-8), reactive oxygen species (ROS). Cell counts at 1, 12, 24 h significantly lower for 2730 VIR (P < 0.05). There no significant change the remaining strains. Neither synthesis nor NMP-41 affected. IL-6 IL-8 stimulated by to different amounts higher levels low virulence. effect on other cytokines. production ROS suppressed. induction an inflammatory keratinocyte response may play a role among host–yeast interactions.
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