Biotransformation of ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, hesperidin, poncirin, glycyrrhizin, and baicalin by human fecal microflora and its relation to cytotoxicity against tumor cells.

摘要: To understand the role of intestinal microflora in biological effect functional herbs, which have been used Korea, Japan, and China as traditional medicines, suggest new bioactive compounds transformed from herbal constituents, metabolic activities herb components (ginsenoside Rb1, crocin, amygdalin, geniposide, puerarin, ginsenoside Re, poncirin, hesperidin, glycyrrhizin, baicalin) toward their (compound K, crocetin, benzaldehyde, genipin, daidzein, Rh1, ponciretin, hesperetin, 18b-glycyrrhetic acid, baicalein) were measured fecal specimens. The these 882.7 +/- 814.5, 3,938.1+/- 2,700.8, 2,375.5 913.7, 1,179.4 795.7, 24.6 10.5, 11.4 10.8, 578.8+/- 206.1, 1,150.0+/- 266.1, 47.3 58.6, 12,253.0 6,527.6 mmol/h/g, respectively. No differences found tested between males females, although individuals are extensively different. metabolites showed more potent cytotoxicity against tumor cells than nonmetabolites. These findings that may activate pharmacological food medicines must be biocatalytic converter for transformation to compounds.