Intestinal, portal, and peripheral profiles of daikenchuto ( TU ‐100)'s active ingredients after oral administration

摘要: A pharmaceutical grade Japanese traditional medicine, daikenchuto (TU-100), consisting of pepper, processed ginger, and ginseng, has been widely used for various intestinal disorders in Japan now under development as a new therapeutic drug the US. It is suggested that TU-100 ingredients exert pharmacological effects on intestines via two routes, from luminal side before absorption peripheral blood stream after absorption. Therefore, order to fully understand actions TU-100, it critically important know intraluminal amounts forms ingested ingredients. In present study, administrating rats, concentrations their conjugates portal ileal contents were determined by LC-MS/MS. Next, was administered patients with ileostomy bags, but whose small are diagnosed healthy, ingredients/conjugates effluent analyzed. The results suggest that: (1) Pepper hydroxysanshools rapidly absorbed enter systemic circulation, (2) Ginseng ginsenosides transported colon least absorption, (3) Ginger gingerols some conjugated intestine vein. While only amount gingerols/gingerol considerable reappear intestine. Thus, effect believed be composite multiple compounds supplied routes.