Protection of Carboxyl Groups

摘要: In synthesis it is often desirable to protect a carboxyl function in order bring about specific reactions elsewhere the molecule and subsequently regenerate original group under conditions which do not affect other sensitive groups substrate. An elegant example of this principle shown route formation 6-aminopenicillamic acid (5) from intermediate (1) [1, 2] general penicillins due Sheehan Henery-Logan [3]. practice, as example, most easily blocked form an ester. Table 5.1, at end Chapter, lists those esters have been widely employed or properties appear be suitable for task. Open image new window