Gastrointestinal Regulatory Peptide Control of Insulin Secretion and its Relevance to Diabetes Mellitus

摘要: An evergrowing number of hormones the gastrointestinal tract (Table 1) have been reported to control insulin secretion either by suppression e.g. somatostatin or stimulation gastric inhibitory polypeptide (GIP). Some these effects are mediated release insulinotropic from gut as part ‘entero-insular axis’. Alternatively peptides within islets Langerhans may act locally paracrine neurocrine mechanisms, through systemic perturb release. This review will concentrate on and pancreas which effects. The chapter initially concept enteroinsular axis be followed a short account those considered relevant carbohydrate metabolism. relevance in disturbances secretion, particular diabetes mellitus, discussed.