THE SEQUENCE OF PORCINE CHROMOGRANIN A MESSENGER RNA DEMONSTRATES CHROMOGRANIN A CAN SERVE AS THE PRECURSOR FOR THE BIOLOGICALLY ACTIVE HORMONE, PANCREASTATIN
作者： ANNA L. IACANGELO , REINER FISCHER-COLBRIE , KERRY J. KOLLER , MICHAEL J. BROWNSTEIN , LEE E. EIDEN
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摘要: Specific oligonucleotide priming of double-stranded DNA has been employed to sequence a porcine chromogranin A adrenomedullary cDNA. Porcine is more than 80% identical human, bovine, and rat at its deduced Nand C-termini. 49-amino acid region the molecule 59–71% homologous corresponding areas rat, human A, amino pancreastatin. The preceded by an arginine Nterminus followed GKR C-terminus. Thus, can serve as precursor for pancreastatin, polypeptide capable inhibiting insulin release from endocrine pancreas secretion parietal cells gut.
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