Loss of the Chromosomal Region 10q23–25 in Prostate Cancer

摘要: Abstract Loss of the chromosomal region 10q23–25 is a frequent event in progression prostate adenocarcinoma. A candidate tumor suppressor gene from this region, Mxi1 at 10q25, has recently been shown to be mutated small number tumors. To more strictly define those regions 10q loss that are likely involved advancement, we have constructed detailed deletion map spanning incorporates Mxi1. Sixty-two % (23 37) tumors analyzed exhibited some degree loss. Our data suggest presence gene(s) near 10q23–24 boundary, which was deleted overwhelming majority (22 23) showing In contrast, specific Mxi1, as opposed other or entire observed only 1 23 and accompanied by markers boundary. Furthermore, failed detect any mutations Mxi1-associated marker either single-strand conformation polymorphism analysis direct DNA sequencing.