microRNA-21 Negatively Regulates Cdc25A and Cell Cycle Progression in Colon Cancer Cells

作者: Peng Wang , Fangdong Zou , Xiaodong Zhang , Hua Li , Austin Dulak

DOI: 10.1158/0008-5472.CAN-09-1996

关键词: Cell growthRNA interferenceCDC25AmicroRNACarcinogenesisMolecular biologyCancer researchGene silencingBiologyCell cycleGene expression profiling

摘要: … , negatively regulates G 1 -S transition, and participates in DNA damage–induced G 2 -M checkpoint through down-regulation … a novel mechanism of Cdc25A regulation and a potential …

参考文章(49)
Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Genetic instabilities in human cancers Nature. ,vol. 396, pp. 643- 649 ,(1998) , 10.1038/25292
Niels Mailand, Alexandre V Podtelejnikov, Anja Groth, Matthias Mann, Jiri Bartek, Jiri Lukas, None, Regulation of G2/M events by Cdc25A through phosphorylation-dependent modulation of its stability The EMBO Journal. ,vol. 21, pp. 5911- 5920 ,(2002) , 10.1093/EMBOJ/CDF567
Chang-Zheng Chen, MicroRNAs as Oncogenes and Tumor Suppressors The New England Journal of Medicine. ,vol. 353, pp. 1768- 1771 ,(2005) , 10.1056/NEJMP058190
Joris Pothof, Nicole S Verkaik, Wilfred van IJcken, Erik A C Wiemer, Van T B Ta, Gijsbertus T J van der Horst, Nicolaas G J Jaspers, Dik C van Gent, Jan H J Hoeijmakers, Stephan P Persengiev, MicroRNA-mediated gene silencing modulates the UV-induced DNA-damage response The EMBO Journal. ,vol. 28, pp. 2090- 2099 ,(2009) , 10.1038/EMBOJ.2009.156
S Goldstone, S Pavey, A Forrest, J Sinnamon, B Gabrielli, Cdc25-dependent activation of cyclin A/cdk2 is blocked in G2 phase arrested cells independently of ATM/ATR. Oncogene. ,vol. 20, pp. 921- 932 ,(2001) , 10.1038/SJ.ONC.1204177
Fanyin Meng, Roger Henson, Hania Wehbe–Janek, Kalpana Ghoshal, Samson T. Jacob, Tushar Patel, MicroRNA-21 regulates expression of the PTEN tumor suppressor gene in human hepatocellular cancer Gastroenterology. ,vol. 133, pp. 647- 658 ,(2007) , 10.1053/J.GASTRO.2007.05.022
Shuomin Zhu, Min-Liang Si, Hailong Wu, Yin-Yuan Mo, MicroRNA-21 targets the tumor suppressor gene tropomyosin 1 (TPM1) Journal of Biological Chemistry. ,vol. 282, pp. 14328- 14336 ,(2007) , 10.1074/JBC.M611393200
Anastasia Goloudina, Hiroshi Yamaguchi, Daria B Chervyakova, Ettore Appella, Albert J Fornace, Jr, Dmitry V Bulavin, None, Regulation of human Cdc25A stability by Serine 75 phosphorylation is not sufficient to activate a S phase checkpoint. Cell Cycle. ,vol. 2, pp. 473- 478 ,(2003) , 10.4161/CC.2.5.482