Evaluation of the Goldmann-Witmer coefficient in the immunological diagnosis of ocular toxocariasis.
作者： Zhu Jian Wang , Min Zhou , Wen Jun Cao , Jian Ji , Ying Wen Bi
DOI: 10.1016/J.ACTATROPICA.2016.02.013
关键词: Antibody 、 Intraocular fluid 、 Immunological Diagnosis 、 Toxocara canis 、 Medicine 、 Immunoglobulin E 、 Canis 、 Immunology 、 Ocular toxocariasis 、 Peripheral blood
摘要: Ocular toxocariasis (OT) is a zoonotic parasitic infection mainly caused by the intraocular tissue invasion of second-stage Toxocara canis or cati larva. Measuring specific anti-T. antibodies in fluid (IF) can increase OT diagnosis accuracy using Goldmann-Witmer coefficient (GWC). However, there no systemic evaluation GWC application immunological OT. To assess for immunodiagnosis ocular toxocariasis, paired IF and serum samples from 72 patients diagnosed with were retrospectively analyzed IgG enzyme linked immunosorbent assay (ELISA). values calculated to determine production. Clinical features other laboratory data recorded, their correlations evaluated. Of patients, 60 (83.33%) showed production confirmed GWC, while nonspecific IgE was found 64/69 (92.75%) cases. No significant correlation among clinical Values peripheral blood lower than those regarding screening, vitreous humor increased local compared aqueous samples. Overall, our results indicate that have referential diagnosing toxocariasis.
sci-hub.se 参考文章(26)
Chrisfouad R. Alabiad, Thomas A. Albini, Carmen I. Santos, Janet L. Davis, Ocular Toxocariasis in a Seronegative Adult. Ophthalmic Surgery and Lasers. ,vol. 45, pp. 1- 3 ,(2014) , 10.3928/15428877-20100325-06
J.-F. Magnaval, L. Malard, B. Morassin, R. Fabre, Immunodiagnosis of ocular toxocariasis using Western-blot for the detection of specific anti-Toxocara IgG and CAP for the measurement of specific anti-Toxocara IgE. Journal of Helminthology. ,vol. 76, pp. 335- 339 ,(2002) , 10.1079/JOH2002143
Graciela Santillán, Vanesa Bastin, Graciela Céspedes, Adriana Monkiewicz, Evaluación de un antígeno purificado para el diagnóstico de toxocariosis Revista Argentina De Microbiologia. ,vol. 45, pp. 80- 85 ,(2013) , 10.1016/S0325-7541(13)70003-8
G. Rubinsky-Elefant, C. E. Hirata, J. H. Yamamoto, M. U. Ferreira, Human toxocariasis: diagnosis, worldwide seroprevalences and clinical expression of the systemic and ocular forms Annals of Tropical Medicine and Parasitology. ,vol. 104, pp. 3- 23 ,(2010) , 10.1179/136485910X12607012373957
Seong Joon Ahn, Se Joon Woo, Yan Jin, Yoon-Seok Chang, Tae Wan Kim, Jeeyun Ahn, Jang Won Heo, Hyeong Gon Yu, Hum Chung, Kyu Hyung Park, Sung Tae Hong, Clinical Features and Course of Ocular Toxocariasis in Adults PLoS Neglected Tropical Diseases. ,vol. 8, pp. e2938- ,(2014) , 10.1371/JOURNAL.PNTD.0002938
Takashi Akiyama, Nobuo Ohta, Parasite-specific antibody profile in the aqueous humor of rabbits with ocular toxocariasis. Parasitology International. ,vol. 59, pp. 112- 120 ,(2010) , 10.1016/J.PARINT.2009.11.002
Dana Woodhall, Michelle C. Starr, Susan P. Montgomery, Jeffrey L. Jones, Flora Lum, Russell W. Read, Ramana S. Moorthy, Ocular toxocariasis: epidemiologic, anatomic, and therapeutic variations based on a survey of ophthalmic subspecialists. Ophthalmology. ,vol. 119, pp. 1211- 1217 ,(2012) , 10.1016/J.OPHTHA.2011.12.013
Andrew J. Schneier, Marlene L. Durand, Ocular toxocariasis: advances in diagnosis and treatment International Ophthalmology Clinics. ,vol. 51, pp. 135- 144 ,(2011) , 10.1097/IIO.0B013E31822D6A5A
H. Goldmann, R. Witmer, Antibodies in the aqueous humor Ophthalmologica. ,vol. 127, pp. 323- 330 ,(1954) , 10.1159/000301976
JAY M. STEWART, LEO D. P. CUBILLAN, EMMETT T. CUNNINGHAM, Prevalence, clinical features, and causes of vision loss among patients with ocular toxocariasis. Retina-the Journal of Retinal and Vitreous Diseases. ,vol. 25, pp. 1005- 1013 ,(2005) , 10.1097/00006982-200512000-00009