Experimental Autoimmune Encephalomyelitis in the Mouse
作者： Stephen D. Miller , William J. Karpus
DOI: 10.1002/0471142735.IM1501S77
关键词: Experimental autoimmune encephalomyelitis 、 Myelin 、 Cell biology 、 Immunology 、 Myelin oligodendrocyte glycoprotein 、 Transgene 、 Encephalomyelitis 、 Proteolipid protein 1 、 Adoptive cell transfer 、 Chemistry 、 Myelin basic protein
摘要: This unit details the materials and methods required for both active induction adoptive transfer of experimental autoimmune encephalomyelitis (EAE) in SJL mouse strain using intact proteins or peptides from two major myelin proteins: proteolipid protein (PLP) basic (MBP). Detailed purification PLP MBP are also described. Modifications specified protocols may be necessary efficient EAE other strains.
sci-hub.se 参考文章(71)
C B Pettinelli, D E McFarlin, Adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice after in vitro activation of lymph node cells by myelin basic protein: requirement for Lyt 1+ 2- T lymphocytes. Journal of Immunology. ,vol. 127, pp. 1420- 1423 ,(1981)
R B Fritz, C H Chou, D E McFarlin, Induction of experimental allergic encephalomyelitis in PL/J and (SJL/J x PL/J)F1 mice by myelin basic protein and its peptides: localization of a second encephalitogenic determinant. Journal of Immunology. ,vol. 130, pp. 191- 194 ,(1983)
V K Kuchroo, R A Sobel, S Southwood, M B Lees, J M Greer, A Sette, Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein. Journal of Immunology. ,vol. 156, pp. 371- 379 ,(1996)
R B Fritz, C H Chou, D E McFarlin, C B Pettinelli, Encephalitogenic activity of guinea pig myelin basic protein in the SJL mouse. Journal of Immunology. ,vol. 129, pp. 1209- 1211 ,(1982)
V K Kuchroo, R A Sobel, M B Lees, J M Greer, Identification and characterization of a second encephalitogenic determinant of myelin proteolipid protein (residues 178-191) for SJL mice. Journal of Immunology. ,vol. 149, pp. 783- 788 ,(1992)
H. Offner, R. H. Whitham, C. M. Hoy, G. A. Hashim, R. E.K Jones, A. A. Vandenbark, Run-Ying Wang, Location of a new encephalitogenic epitope (residues 43 to 64) in proteolipid protein that induces relapsing experimental autoimmune encephalomyelitis in PL/J and (SJL x PL)F1 mice. Journal of Immunology. ,vol. 147, pp. 3803- 3808 ,(1991)
Stephen D. Miller, Lit Jen Tan, Mary K. Kennedy, Regulation of the effector stages of experimental autoimmune encephalomyelitis via neuroantigen-specific tolerance induction. II. Fine specificity of effector T cell inhibition. Journal of Immunology. ,vol. 148, pp. 2748- 2755 ,(1992)
Fred D. Lublin, Delayed, relapsing experimental allergic encephalomyelitis in mice: Role of adjuvants and pertussis vaccine Journal of the Neurological Sciences. ,vol. 57, pp. 105- 110 ,(1982) , 10.1016/0022-510X(82)90114-9
R. A. Sobel, M. B. Lees, Vincent K Tuohy, R. A. Laursen, Z. Lu, Identification of an encephalitogenic determinant of myelin proteolipid protein for SJL mice. Journal of Immunology. ,vol. 142, pp. 1523- 1527 ,(1989)
W J Karpus, N W Lukacs, R M Strieter, B L McRae, S D Miller, S L Kunkel, An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis. Journal of Immunology. ,vol. 155, pp. 5003- 5010 ,(1995)