Airway hyperresponsiveness; smooth muscle as the principal actor.

摘要: Airway hyperresponsiveness (AHR) is a defining characteristic of asthma that refers to the capacity airways undergo exaggerated narrowing in response stimuli do not result comparable degrees airway healthy subjects. smooth muscle (ASM) contraction mediates narrowing, but it remains uncertain as whether intrinsically altered asthmatic subjects or responding abnormally milieu which sits. ASM trachea major bronchi does differ its contractile characteristics asthmatics, more pertinent peripheral await complete exploration. The mass increased many all asthmatics and therefore cannot be unifying hypothesis for AHR, although when may contribute AHR. inability deep breath reverse prevent bronchial reflect an intrinsic difference mechanisms lead softening contracted subjected stretch. Cytokines such interleukin-13 tumor necrosis factor-α promote phenotype. composition stiffness matrix embedded promotes proliferative pro-inflammatory phenotype, expected dedifferentiation loss contractility have been shown. epithelium drive proliferation and/or molecular remodeling ways In conclusion, AHR likely multifactorial origin, reflecting plasticity properties inflammatory environment airway.