Improved Survival Associated With Postoperative Wound Infection in Dogs Treated With Limb-Salvage Surgery for Osteosarcoma

摘要: Limb-salvage surgery and adjuvant chemotherapy are performed as a treatment of appendicular osteosarcoma in dogs. Approximately 50% dogs that undergo limb-salvage develop postoperative surgical wound infections. Postoperative infections may affect survival cancer patients. The purposes this study were to examine the effect infection on survival, local recurrence, metastasis relation other prognostic factors for with spontaneous treated surgery. Forty-seven client-owned distal radius chemotherapy—either carboplatin or doxorubicin. Hazard ratios estimated by using Cox proportional hazard model, functions Kaplan-Meier product-limit life-table method. Of 47 study, 32 (68%) developed infection. Infection, dog weight, extent primary tumor (percentage length) significantly affected percentage length time metastasis. None variables considered recurrence. Dogs diagnosed an less likely die (hazard ratio, .446), greater body weight involvement more 3.37 3.66, respectively). In surgery, has positive influence does smaller initial involved lower weight.