Corpus callosum signal intensity in patients with bipolar and unipolar disorder
作者： A. G. Mallinger , P. Brambilla , M. S. Keshavan , E. Frank , Jair C Soares
关键词: In patient 、 Bipolar disorder 、 Corpus callosum 、 Magnetic resonance imaging 、 White matter 、 Splenium 、 Anatomy 、 Neuroscience 、 First episode 、 Psychology 、 Signal intensity
摘要: Background: Anatomical abnormalities in the corpus callosum have been reported magnetic resonance imaging (MRI) studies patients with bipolar but not unipolar disorder. MRI signal intensity can be used as a putative index of myelination. Objectives: To measure and disorder to investigate myelination. Methods: The study involved 29 DSM-IV (mean (SD) age, 35 (11) years; 16 male, 13 female), 23 (41 (10) 4 19 36 healthy controls (37 female). A 1.5T GE Signa magnet was employed, fast spin echo sequence. Corpus obtained blindly using semiautomated software NIH Image 1.62. Results: Bipolar had lower for all callosal subregions (genu, anterior posterior body, isthmus, splenium) than (ANCOVA, age sex covariates, p 0.05). Conclusions: findings suggest white matter patients, possibly because altered myelination. Such could lead impaired interhemispheric communication Longitudinal involving first episode early onset will necessary better understanding potential role myelination pathophysiology
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