The role of receptor interactions in regulating ethylene signal transduction.
作者： Zhiyong Gao , G. Eric Schaller
关键词: Ethylene signal transduction 、 Receptor 、 Order (biology) 、 Chemoreceptor 、 Biology 、 Biochemistry 、 Mechanism (biology) 、 Ethylene 、 Cooperativity 、 Arabidopsis 、 Cell biology
摘要: The phytohormone ethylene is perceived in Arabidopsis by a five-member receptor family. Earlier work has demonstrated that the basic functional unit for an disulfide-linked homodimer. We recently reported Journal of Biological Chemistry ethylene-receptor ETR1 physically associates with other receptors through higher order interactions, suggesting existence clusters. Here we consider implications such clusters upon mechanism signal transduction. In particular, how clustering provides cooperative mechanism, akin to what been found prokaryotic chemoreceptors, which plant sensitivity may be increased. addition, dominant insensitivity conferred some mutations, as etr1-1, also propagated interactions among members
sci-hub.se 参考文章(19)
Kyeong Kyu Kim, Hisao Yokota, Sung-Hou Kim, Four-helical-bundle structure of the cytoplasmic domain of a serine chemotaxis receptor Nature. ,vol. 400, pp. 787- 792 ,(1999) , 10.1038/23512
G. E. Schaller, A. B. Bleecker, Ethylene-Binding Sites Generated in Yeast Expressing the Arabidopsis ETR1 Gene Science. ,vol. 270, pp. 1809- 1811 ,(1995) , 10.1126/SCIENCE.270.5243.1809
N. R. Francis, P. M. Wolanin, J. B. Stock, D. J. DeRosier, D. R. Thomas, Three-dimensional structure and organization of a receptor/signaling complex. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 101, pp. 17480- 17485 ,(2004) , 10.1073/PNAS.0407826101
K. L. Clark, P. B. Larsen, X. Wang, C. Chang, Association of the Arabidopsis CTR1 Raf-like kinase with the ETR1 and ERS ethylene receptors Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 5401- 5406 ,(1998) , 10.1073/PNAS.95.9.5401
Maddock, L Shapiro, Polar location of the chemoreceptor complex in the Escherichia coli cell Science. ,vol. 259, pp. 1717- 1723 ,(1993) , 10.1126/SCIENCE.8456299
Peter M Wolanin, Jeffry B Stock, Bacterial Chemosensing: Cooperative Molecular Logic Current Biology. ,vol. 14, pp. R486- R487 ,(2004) , 10.1016/J.CUB.2004.06.018
Joseph J. Kieber, Madge Rothenberg, Gregg Roman, Kenneth A. Feldmann, Joseph R. Ecker, CTR1, a negative regulator of the ethylene response pathway in Arabidopsis, encodes a member of the raf family of protein kinases Cell. ,vol. 72, pp. 427- 441 ,(1993) , 10.1016/0092-8674(93)90119-B
B. Christoffer Lagerholm, Nancy L. Thompson, Theory for Ligand Rebinding at Cell Membrane Surfaces Biophysical Journal. ,vol. 74, pp. 1215- 1228 ,(1998) , 10.1016/S0006-3495(98)77836-1
Zhiyong Gao, Yi-Feng Chen, Melynda D. Randlett, Xue-Chu Zhao, Jennifer L. Findell, Joseph J. Kieber, G. Eric Schaller, Localization of the Raf-like Kinase CTR1 to the Endoplasmic Reticulum of Arabidopsis through Participation in Ethylene Receptor Signaling Complexes Journal of Biological Chemistry. ,vol. 278, pp. 34725- 34732 ,(2003) , 10.1074/JBC.M305548200
F. I. Rodriguez, J. J. Esch, A. E. Hall, B. M. Binder, G. E. Schaller, A. B. Bleecker, A Copper Cofactor for the Ethylene Receptor ETR1 from Arabidopsis Science. ,vol. 283, pp. 996- 998 ,(1999) , 10.1126/SCIENCE.283.5404.996