Thyroid hormone action on lipid metabolism in humans: a role for endogenous insulin.
作者： M.J. Müller , K.J. Acheson , E. Jequier , A.G. Burger
DOI: 10.1016/0026-0495(90)90006-X
关键词: Internal medicine 、 Lipid metabolism 、 Ketone bodies 、 Metabolism 、 Biology 、 Endocrinology 、 Insulin 、 Lipolysis 、 Fatty acid 、 Ketogenesis 、 Lipid oxidation
摘要: Abstract The effects of moderate hyperthyroidism on lipid metabolism were investigated in six healthy subjects before and after thyroxine treatment (300 μg/d). T4-treatment increased basal metabolic rate (+8%) glucose oxidation (+87%), without affecting oxidation, plasma free fatty acids, glycerol, β-hydroxybutyrate. During euthyroidism, a hypoinsulinaemic-euglycaemic 150-minute clamp protocol energy expenditure (+3%), (+42%), acids (+254%), glycerol (+232%), β-hydroxybutyrate (+343%), but decreased (−20%). Similar observed T4-treatment, induced disproportionate increases (+7%), (+310%), ketone body levels (+436%). We conclude that enhances hypoinsulinemia-induced lipolysis, acid recycling, ketogenesis oxidation. Thus insulin may camouflage some thyroid hormone action metabolism.
elsevier.com
sci-hub.se 参考文章(40)
F. Sandhofer, S. Sailer, H. Braunsteiner, Fettsäure- und Triglyceridumsatz bei Schilddrüsenüberfunktion Journal of Molecular Medicine. ,vol. 44, pp. 1389- 1393 ,(1966) , 10.1007/BF01752479
J M Miles, M W Haymond, S L Nissen, J E Gerich, Effects of free fatty acid availability, glucagon excess, and insulin deficiency on ketone body production in postabsorptive man. Journal of Clinical Investigation. ,vol. 71, pp. 1554- 1561 ,(1983) , 10.1172/JCI110911
J.-P. Felber, A. Vannotti, EFFECTS OF FAT INFUSION ON GLUCOSE TOLERANCE AND INSULIN PLASMA LEVELS. Medicina experimentalis. International journal of experimental medicine. ,vol. 10, pp. 153- 156 ,(1964) , 10.1159/000135410
U. Paschen, H. J. Seitz, M. J. Müller, P. E. Mitchinson, Glucoregulatory function of glucagon in hypo-, eu- and hyperthyroid miniature pigs Diabetologia. ,vol. 31, pp. 368- 374 ,(1988) , 10.1007/BF02341505
Robert A. Gelfand, Karen A. Hutchinson-Williams, Alfons A. Bonde, Pietro Castellino, Robert S. Sherwin, Catabolic effects of thyroid hormone excess: the contribution of adrenergic activity to hypermetabolism and protein breakdown Metabolism-clinical and Experimental. ,vol. 36, pp. 562- 569 ,(1987) , 10.1016/0026-0495(87)90168-5
MANFRED J. MÜLLER, ULRICH PASCHEN, HANS J. SEITZ, A.TECHNICAL ASSISTANCE HARNEIT, D. LUDA, Thyroid Hormone Regulation of Glucose Homeostasis in the Miniature Pig Endocrinology. ,vol. 112, pp. 2025- 2031 ,(1983) , 10.1210/ENDO-112-6-2025
B. Wilander, Active State Durations of Rat Gastrocnemius Muscle Acta Physiologica Scandinavica. ,vol. 68, pp. 1- 17 ,(1966) , 10.1111/J.1748-1716.1966.TB03395.X
Manfred J. Müller, Hans J. Seitz, Interrelation between thyroid state and the effect of glucagon on gluconeogenesis in perfused rat livers Biochemical Pharmacology. ,vol. 36, pp. 1623- 1627 ,(1987) , 10.1016/0006-2952(87)90046-3
Jacob A. Stakkestad, Henrik Lund, The effect of nutritional and thyroid state on the distribution of fatty acids between oxidation and esterification in isolated rat hepatocytes Biochimica et Biophysica Acta. ,vol. 793, pp. 1- 9 ,(1984) , 10.1016/0005-2760(84)90046-8
H Miyoshi, G I Shulman, E J Peters, M H Wolfe, D Elahi, R R Wolfe, Hormonal control of substrate cycling in humans. Journal of Clinical Investigation. ,vol. 81, pp. 1545- 1555 ,(1988) , 10.1172/JCI113487