Chapter 3 Studies on The Control of Differentiation of Murine Virus-Induced Erythroleukemic Cells*

摘要: Publisher Summary The chapter discusses about the murine virus-induced leukemia (FLV) that serves as a model system for exploring relationship between differentiation and malignancy. cells of this (FLC) differentiate along erythroid pathway in vitro and, under special conditions, vivo well. Reports on tumor include: studies human neuroblastoma well leukemic cells. describe malignant possess at least some genetic information controls growth fate their normal counterparts. Recent acute lymphoblastic demonstrate presence terminal deoxynucleotidyl transferase, an enzyme found only thymus cells, indicating there is retention certain specific tissue origin. It was observed FLC, cultured DMSO or DMF alone combination with BUdR, increased numbers budding viruses cell membranes. appeared synthesizing Type C virus particles are not necessarily malignant, agents (DMSO, DMF) stimulate differentiation, concomitant decrease potential also number particles. BUdR inhibits yet, increases viruses.