Ionic liquid induced G-quadruplex formation and stabilization: spectroscopic and simulation studies
作者： Sagar Satpathi , Mandar Kulkarni , Arnab Mukherjee , Partha Hazra
DOI: 10.1039/C6CP05732B
关键词: Guanine 、 Ionic liquid 、 Tris 、 Cellular Aging 、 DNA 、 Analytical chemistry 、 Ion 、 G-quadruplex 、 Chemistry 、 Molecular dynamics 、 Crystallography
摘要: Among different polymorphs of DNA, G-quadruplex (GQ) formation in guanine rich sequences has received special attention due to its direct relevance cellular aging and abnormal cell growths. To date, smaller ions like Na+, K+, Li+, NH4+ are the best possible selective GQ stabilizing materials. Herein, we report that an ionic liquid (IL), i.e. guanidinium tris(pentafluoroethyl)trifluorophosphate, can not only instigate absence conventional forming (like NH4+, etc.), but also stabilizes structure. This conformational transition been confirmed through spectroscopic tools molecular dynamics (MD) simulation studies. MD shows one cations resides G-tetrad core, while bulky anions prefer stay near surface resulting stabilization. study thus brings out a type acts as stabilizer. The origin stabilization by IL presented here may help future design for
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