Krüppel-like Factors KLF6 and KLF6-SV1 in the Diagnosis and Treatment of Cancer
作者： Analisa DiFeo , Goutham Narla , John A. Martignetti
DOI: 10.1007/978-4-431-87775-2_17
关键词: Kruppel-like factors 、 Cancer research 、 Disease 、 KLF6 、 Suppressor 、 Ovarian cancer 、 Medicine 、 Prostate cancer 、 Cancer 、 Epidemiology of cancer
摘要: Beyond their initial identification in prostate cancer, the tumor suppressor KLF6 and its alternatively spliced oncogenic isoform KLF6-SV1 have now been associated with a number of human cancers. Expression patterns each linked to stage, disease recurrence, chemotherapy response overall survival. Most recently, inhibition has shown increase survival pre-clinical model ovarian cancer. This chapter reviews basic biology as it relates summarizes published studies date, highlights scientific rationale for therapeutically targeting novel treatment paradigm.
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