Pharmacokinetic rationale for peritoneal drug administration in the treatment of ovarian cancer

摘要: Evidence from the peritoneal dialysis literature suggests that permeability of a number hydrophilic anticancer drugs may be considerably less than plasma clearance. Pharmacokinetic calculations indicate such administered ip in large volumes are expected to maintain significantly greater concentration space plasma. This difference offers potentially exploitable biochemical advantage treatment patients with presumed microscopic residual ovarian cancer confined cavity.