The disposition of intraperitoneal bleomycin, melphalan, and vinblastine in cancer patients.

摘要: We have studied the disposition of bleomycin, melphalan, or vinblastine after intraperitoneal (IP) instillation in 14 cancer patients. Although IP bleomycin had a somewhat longer terminal-phase plasma half-life than intravenous (IV) administration (5.5 vs 4.0 h, respectively), its systemic absorption averaged only 44%–52% administered dose. melphalan’s mean 1.3 h was similar to that seen IV drug administration. Melphalan’s from space 39% In contrast, levels remained elevated for 24 instillation. Its use associated with life-threatening adynamic ileus two Bleomycin’s and reduced availability dosing suggests their dose could be increased safely by factor over standard doses.