Pharmacokinetics and pharmacodynamics of perioperative cancer chemotherapy in peritoneal surface malignancy.

摘要: The peritoneal surface remains an important failure site for patients with gastrointestinal and gynecologic malignancies. During the last 2 decades, novel therapeutic approaches, combining cytoreductive surgery intraoperative intracavitary intravenous chemotherapy, have emerged carcinomatosis patients. This has resulted in remarkable clinical successes contrast prior failures. Although further data from phase II III trials supporting this combined treatment protocols are necessary, optimalization of wide variety different perioperative cancer chemotherapy used these regimens is equally important. To date, a clear understanding pharmacology still lacking. efficacy intraperitoneal governed as much by nonpharmacokinetic variables (tumor nodule size, density, vascularity, interstitial fluid pressure, binding) pharmacokinetic (dose, volume, duration, carrier solution). Our recent support importance tumor most meaningful pharmacologic end point. Timing may substantially influence pharmacokinetics. review aims to clarify pharmacodynamic currently available regarding delivery agents carcinomatosis.