Bleomycin Pulmonary Toxicity

摘要: Bleomycin, a new antitumor antibiotic with known pulmonary toxic properties, was administered to patient disseminated Kaposi's sarcoma. At relatively low total dose (180 mg) the developed diffuse interstitial pneumonitis and died of respiratory failure. Massive corticosteroid therapy had no beneficial effect Tumor regression fibrosis were documented at autopsy. Light microscopic immunofluorescence studies lung tissue suggest that similar busulfan hexamethonium, injury most likely due direct toxicity rather than true drug hypersensitivity.