Human papillomavirus oropharynx carcinoma: Aggressive de-escalation of adjuvant therapy.
作者： Eric J. Moore , Kathryn M. Van Abel , David M. Routman , Christine M. Lohse , Katharine A. R. Price
DOI: 10.1002/HED.26477
关键词: Oncology 、 Confidence interval 、 Neck dissection 、 Hazard ratio 、 Clinical trial 、 Interquartile range 、 De-escalation 、 Cohort 、 Internal medicine 、 Medicine 、 Adjuvant therapy
摘要: Background Aggressive dose de-escalated adjuvant radiation therapy (RT) in patients with human papillomavirus-associated oropharyngeal squamous cell carcinoma (HPV(+)OPSCC). Methods Patients HPV(+)OPSCC on a phase II clinical trial of primary surgery and neck dissection followed by RT (N = 79) were compared cohort who received standard 115). Local recurrence-free, regional distant metastases-free survival, progression-free survival (PFS) assessed. Results Of 194 patients, 23 experienced progression at median 1.1 years following (interquartile range [IQR] 0.7-2.0; 0.3-5.4); 10 the 13 cohort. The 3-year PFS rate for was 87%, 90% (hazard ratio [HR] 1.18, 95% confidence interval (CI) [0.50-2.75]). Conclusion undergo surgical resection meet criteria can aggressive de-escalation without increasing risk locally, regionally or sites.
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