A randomized trial of primary liver transplantation under immunosuppression with FK 506 vs cyclosporine

摘要: THE USE of cyclosporine (CyA) has greatly impacted the success liver transplantation. FK 506 is a newly described immunosuppressive agent, with mechanisms action similar to those CyA, but more potent on weight-to-weight basis. Pilot studies in primary transplantation have shown encouraging results.1 A randomized trial using low-dose steroids (LDS) was compared two different CyA regimens, one LDS and other standard steroid therapy (SST). The end point examine incidence rejection following transplantation, compare graft patient survival rates after LDS, SST.